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by Roncero, Carlos; Vega, Pablo; Martinez-Raga, Jose; Barral, Carmen; Basurte-Villamor, Ignacio; Rodriguez-Cintas, Laia; Mesias, Beatriz; Grau-Lopez, Lara; Casas, Miguel; Szerman, Nestor
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This article is from International Journal of Mental Health Systems , volume 8 . Abstract Background: Since provision of integrated services for patients with dual pathology or dual disorders (coexistence of an addictive disorder and other psychiatric disorders) constitutes an important challenge, this study compared the perceptions of health-care professionals with the existing, current state of specific resources for patients with dual pathology in Spain. Methods: Epidemiological,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158069
PubMed Central
by Child, Nicholas; Muhr, Tina; Sammut, Eva; Dabir, Darius; Ucar, Eduardo Arroyo; Bueser, Tootie; Gill, Jaswinder; Carr-White, Gerry; Nagel, Eike; Puntmann, Valentina O
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract Background: Myocardial crypts are discrete clefts or fissures in otherwise compacted myocardium of the left ventricle (LV). Recent reports suggest a higher prevalence of crypts in patients with hypertrophic cardiomyopathy (HCM) and also within small samples of genotype positive but phenotype negative relatives. The presence of a crypt has been suggested to be a predictor of gene carrier status. However, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164788
PubMed Central
by Pafitis, Natalie
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This article is from BMC Public Health , volume 13 . Abstract Contributing reviewers: The editors of BMC Public Health would like to thank all our reviewers who have contributed to the journal in 2012.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751667
PubMed Central
by Akpinar, Evrim Eylem; Hosgun, Derya; Akpynar, Serdar; Atac, Gokce Kaan; Doganay, Beyza; Gulhan, Meral
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This article is from Jornal Brasileiro de Pneumologia : Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia , volume 40 . Abstract OBJECTIVE:: Because pulmonary embolism (PE) and COPD exacerbation have similar presentations and symptoms, PE can be overlooked in COPD patients. Our objective was to determine the prevalence of PE during COPD exacerbation and to describe the clinical aspects in COPD patients diagnosed with PE. METHODS:: This was a prospective study conducted at...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075911
This article is from GMS Zeitschrift für Medizinische Ausbildung , volume 31 . Abstract The practice of assessing student performance in human, dental and veterinary medicine at universities in German-speaking countries has undergone significant changes in the past decade. Turning the focus to practical requirements regarding medical practice during undergraduate study away from an often theory-dominated curriculum, the academic scrutiny of the basics of teaching medical knowledge and skills,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152998
PubMed Central
by Cunha, Cynthia Braga; De Boni, Raquel Brandini; Guimaraes, Maria Regina Cotrim; Yanavich, Carolyn; Veloso, Valdilea Goncalves; Moreira, Ronaldo Ismerio; Hoagland, Brenda; Grinsztejn, Beatriz; Friedman, Ruth Khalili
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This article is from BMC Public Health , volume 14 . Abstract Background: Many countries are facing concentrated HIV epidemics among vulnerable populations, including men who have sex with men (MSM). Unprotected anal intercourse (UAI) is the main HIV transmission route among them and its understanding in the different cultures and how it relates to HIV transmission, re-infection and development of HIV antiretroviral resistance has important public health implications. Data on UAI among...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005457
PubMed Central
by Bertram, Anna; Haenel, Sascha Sebastian; Hadem, Johannes; Hoeper, Marius M; Gottlieb, Jens; Warnecke, Gregor; Kaschinski, Stanislav; Hafer, Carsten; Kuhn-Velten, W Nikolaus; Gunther, Detlef; Kielstein, Jan T
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This article is from BMC Pharmacology & Toxicology , volume 14 . Abstract Background: Paraquat is a highly toxic herbicide, which not only leads to acute organ damage, but also to pulmonary fibrosis. There are only anecdotal reports of rescue lung transplantation, as paraquat is stored and only slowly released from different tissues. Bridging the time to complete depletion of paraquat from the body could render this exceptional therapy strategy possible, but not much is known on the time...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847611
PubMed Central
by Metz, Claudia HD; Scheulen, Max; Bornfeld, Norbert; Lohmann, Dietmar; Zeschnigk, Michael
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This article is from Cancer Medicine , volume 2 . Abstract Elevated levels of cell-free DNA (cfDNA) are frequently observed in tumor patients. Activating mutations in exon 4 (R183) and exon 5 (Q209) of GNAQ and GNA11 are almost exclusively found in uveal melanoma, thus providing a highly specific marker for the presence of circulating tumor DNA (ctDNA). To establish a reliable, noninvasive assay that might allow early detection and monitoring of metastatic disease, we determined the proportion...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639659
PubMed Central
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This article is from Frontiers in Computational Neuroscience , volume 8 . Abstract Interaural time differences (ITDs) are a main cue for sound localization and sound segregation. A dominant model to study ITD detection is the sound localization circuitry in the avian auditory brainstem. Neurons in nucleus laminaris (NL) receive auditory information from both ears via the avian cochlear nucleus magnocellularis (NM) and compare the relative timing of these inputs. Timing of these inputs is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143899
PubMed Central
by Schuff-Werner, Peter; Steiner, Michael; Fenger, Sebastian; Gross, Hans-Jurgen; Bierlich, Alexa; Dreissiger, Katrin; Mannuss, Steffen; Siegert, Gabriele; Bachem, Maximilian; Kohlschein, Peter
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This article is from British Journal of Haematology , volume 162 . Abstract Pseudothrombocytopenia remains a challenge in the haematological laboratory. The pre-analytical problem that platelets tend to easily aggregate in vitro, giving rise to lower platelet counts, has been known since ethylenediamine-tetra acetic acid EDTA and automated platelet counting procedures were introduced in the haematological laboratory. Different approaches to avoid the time and temperature dependent in vitro...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796857
PubMed Central
by Hombach, Antje; Ommen, Gabi; Chrobak, Mareike; Clos, Joachim
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This article is from Cellular Microbiology , volume 15 . Abstract The heat shock protein 90 plays a pivotal role in the life cycle control of Leishmania donovani promoting the fast-growing insect stage of this parasite. Equally important for insect stage growth is the co-chaperone Sti1. We show that replacement of Sti1 is only feasible in the presence of additional Sti1 transgenes indicating an essential role. To better understand the impact of Sti1 and its interaction with Hsp90, we performed...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654555
PubMed Central
by Breider, Sven; Scheuner, Carmen; Schumann, Peter; Fiebig, Anne; Petersen, Jorn; Pradella, Silke; Klenk, Hans-Peter; Brinkhoff, Thorsten; Goker, Markus
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This article is from Frontiers in Microbiology , volume 5 . Abstract Earlier phylogenetic analyses of the marine Rhodobacteraceae (class Alphaproteobacteria) genera Leisingera and Phaeobacter indicated that neither genus might be monophyletic. We here used phylogenetic reconstruction from genome-scale data, MALDI-TOF mass-spectrometry analysis and a re-assessment of the phenotypic data from the literature to settle this matter, aiming at a reclassification of the two genera. Neither Phaeobacter...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127530
PubMed Central
by Harris, Philippa K
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This article is from BMC Microbiology , volume 13 . Abstract Contributing reviewers: The editors of BMC Microbiology would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576289
PubMed Central
by Dias, Fernando Braga Stehling; Quartier, Marion; Diotaiuti, Lileia; Mejia, Guy; Harry, Myriam; Lima, Anna Carolina Lustosa; Davidson, Robert; Mertens, Frederic; Lucotte, Marc; Romana, Christine A
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This article is from Parasites & Vectors , volume 7 . Abstract Background: The rising number of acute cases of Chagas disease in the State of Pará, reported in the past two decades, has been associated, in part, with the ingestion of juice of local palm tree fruits, mainly açaí berry and bacaba. Near the study area, in Santarém, Pará State, an outbreak of Chagas disease has been notified and investigations suggest the consumption of bacaba juice as the main source of infection with T....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974420
PubMed Central
by Dujic, Tanja; Bego, Tamer; Mlinar, Barbara; Semiz, Sabina; Malenica, Maja; Prnjavorac, Besim; Ostanek, Barbara; Marc, Janja; Causevic, Adlija
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This article is from Biochemia Medica , volume 22 . Abstract Introduction:: The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of the hormonally inactive cortisone to active cortisol, thus facilitating glucocorticoid receptor activation in target tissues. Increased expression of 11β-HSD1 in adipose tissue has been associated with obesity and insulin resistance. In this study, we investigated the association of two 11β-HSD1 gene (HSD11B1) polymorphisms...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062331
PubMed Central
by Desmond, Chris; Brubaker, Kathryn A.; Ellner, Andrew L.
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This article is from Health Psychology and Behavioral Medicine , volume 1 . Abstract Context: People do not always make health-related decisions which reflect their best interest – best interest being defined as the decision they would make if they carefully considered the options and fully understood the information available. A substantial literature has developed in behavioral economics and social psychology that seeks to elucidate the patterns in individual decision-making. While this is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164239
PubMed Central
by Weidner, Stefan; Baumgarth, Birgit; Gottfert, Michael; Jaenicke, Sebastian; Puhler, Alfred; Schneiker-Bekel, Susanne; Serrania, Javier; Szczepanowski, Rafael; Becker, Anke
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This article is from Genome Announcements , volume 1 . Abstract Sinorhizobium meliloti Rm41 nodulates alfalfa plants, forming indeterminate type nodules. It is characterized by a strain-specific K-antigen able to replace exopolysaccharides in promotion of nodule invasion. We present the Rm41 genome, composed of one chromosome, the chromid pSymB, the megaplasmid pSymA, and the nonsymbiotic plasmid pRme41a.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556828
PubMed Central
by Keller, Maria; Liu, Xuanshi; Wohland, Tobias; Rohde, Kerstin; Gast, Marie-Therese; Stumvoll, Michael; Kovacs, Peter; Tonjes, Anke; Bottcher, Yvonne
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This article is from PLoS ONE , volume 8 . Abstract Background: Genetic variants within the bitter taste receptor gene TAS2R38 are associated with sensitivity to bitter taste and are related to eating behavior in the Amish population. Sensitivity to bitter taste is further related to anthropometric traits in an genetically isolated Italian population. We tested whether the TAS2R38 variants (rs713598; rs1726866 and rs10246939) may be related to eating behavior, anthropometric parameters,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846558
PubMed Central
by Thomaidis, Thomas; Maderer, Annett; Al-Batran, Salah-Eddin; Kany, Janis; Pauligk, Claudia; Steinmetz, Kristina; Schad, Arno; Hofheinz, Ralf; Schmalenberg, Harald; Homann, Nils; Galle, Peter Robert; Moehler, Markus
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This article is from BMC Cancer , volume 14 . Abstract Background: Combination of fluoropyrimidines and a platinum derivative are currently standards for systemic chemotherapy in advanced adenocarcinoma of the stomach and gastroesophageal junction (GEJ). Nevertheless, individual likelihood for response to these therapeutic regimes remains uncertain. Even more, no predictive markers are available to determine which patients may benefit more from oxaliplatin versus cisplatin or vice versa. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094395
PubMed Central
by Petersen, Wolf; Ellermann, Andree; Rembitzki, Ingo Volker; Scheffler, Sven; Herbort, Mirco; Sprenker, Frederike Sophie; Achtnich, Andrea; Bruggemann, Gert Peter; Best, Raymond; Hoffmann, Frank; Koppenburg, Andreas Gosele; Liebau, Christian
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This article is from BMC Musculoskeletal Disorders , volume 15 . Abstract Background: Patellofemoral pain syndrome (PFPS) is a frequent cause of anterior knee pain predominantly affecting young female patients who do not have significant chondral damage. Development of PFPS is probably multifactorial, involving various knee, hip, and foot kinematic factors. Biomechanical studies have described patellar maltracking and dynamic valgus (functional malalignment) in patients with patellofemoral pain...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089925
PubMed Central
by Amir, Lisa
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This article is from International Breastfeeding Journal , volume 9 . Abstract Contributing reviewers: The editor of International Breastfeeding Journal would like to thank all our reviewers who have contributed to the journal in Volume 8 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925953
PubMed Central
by Eguchi, Y; Gando, S; Ishikura, H; Saitoh, D; Mimuro, J; Takahashi, H; Kitajima, I; Tsuji, H; Matsushita, T; Sakata, Y
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This article is from Critical Care , volume 18 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068652
PubMed Central
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This article is from Experimental & Translational Stroke Medicine , volume 4 . Abstract From November 4th- 6th 2011, the 3rd NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. Like in the previous years, the meeting provided an excellent platform for scientific exchange and the presentation of innovative projects for young colleagues in the fields of neurovascular research, neuroinflammation and neurodegeneration. As kick-off to the scientific sessions, Reinhard Hohlfeld, Head...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299621
PubMed Central
by Foote, Christopher
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This article is from BMC Research Notes , volume 7 . Abstract Contributing reviewers: The editors of BMC Research Notes would like to thank all of our reviewers who have contributed to the journal in volume 6 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895785
PubMed Central
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This article is from The Libyan Journal of Medicine , volume 9 . Abstract Domestic violence (DV) is quite prevalent and negatively impacts the health and mental wellbeing of those affected. Victims of DV are frequent users of health service, yet they are infrequently recognized. Physicians tend to treat the presenting complaints without addressing the root cause of the problem. Lack of knowledge on adequately managing cases of DV and on appropriate ways to help survivors is commonly presented...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957738
PubMed Central
by Quiroga, Rodrigo; Meneses, Lidia; Bussmann, Rainer W
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This article is from Journal of Ethnobiology and Ethnomedicine , volume 8 . Abstract Background: The aim of this study was to document the types of diseases treated by the use of medicinal plants, their main applications and also to have a report of the major diseases treated at the Hospital of San Pablo de Huacareta (Chuquisaca Bolivia). Methods: We conducted semi-structured interviews on the use medicinal plants with 10 local informants, and categorized the kinds of diseases treated by...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484016
PubMed Central
by Akhtar, Syed Tehseen; Mahmood, Khalid; Naqvi, Iftikhar Haider; Vaswani, Aneel Sham
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This article is from Pakistan Journal of Medical Sciences , volume 30 . Abstract Objective: To assess inpatient management of non-critically ill type 2 diabetics with different insulin regimen.Methods: We reviewed the medical records of all non-critically ill type 2 diabetic patients more than 18 years of age in medical department of civil hospital Karachi and Dow University of Health Sciences from January 2011 to December 2012. We collected the data from case records in data collection sheets...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121721
PubMed Central
by Niessner, Heike; Forschner, Andrea; Klumpp, Bernhard; Honegger, Jurgen B.; Witte, Maria; Bornemann, Antje; Dummer, Reinhard; Adam, Annemarie; Bauer, Jurgen; Tabatabai, Ghazaleh; Flaherty, Keith; Sinnberg, Tobias; Beck, Daniela; Leiter, Ulrike; Mauch, Cornelia; Roesch, Alexander; Weide, Benjamin; Eigentler, Thomas; Schadendorf, Dirk; Garbe, Claus; Kulms, Dagmar; Quintanilla-Martinez, Leticia; Meier, Friedegund
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This article is from Cancer Medicine , volume 2 . Abstract Brain metastases are the most common cause of death in patients with metastatic melanoma, and the RAF-MEK-ERK and PI3K-AKT signaling pathways are key players in melanoma progression and drug resistance. The BRAF inhibitor vemurafenib significantly improved overall survival. However, brain metastases still limit the effectiveness of this therapy. In a series of patients, we observed that treatment with vemurafenib resulted in substantial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797558
PubMed Central
by Solera, Dafne
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This article is from BMC Cancer , volume 14 . Abstract Contributing reviewers: The editors of BMC Cancer would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909450
PubMed Central
by Beecham, Gary W.; Hamilton, Kara; Naj, Adam C.; Martin, Eden R.; Huentelman, Matt; Myers, Amanda J.; Corneveaux, Jason J.; Hardy, John; Vonsattel, Jean-Paul; Younkin, Steven G.; Bennett, David A.; De Jager, Philip L.; Larson, Eric B.; Crane, Paul K.; Kamboh, M. Ilyas; Kofler, Julia K.; Mash, Deborah C.; Duque, Linda; Gilbert, John R.; Gwirtsman, Harry; Buxbaum, Joseph D.; Kramer, Patricia; Dickson, Dennis W.; Farrer, Lindsay A.; Frosch, Matthew P.; Ghetti, Bernardino; Haines, Jonathan L.;...
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This article is from PLoS Genetics , volume 10 . Abstract Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of known genetic risk loci for AD dementia using neuropathologic data from 4,914 brain autopsies. Neuropathologic data were used to define clinico-pathologic AD dementia or controls, assess core...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154667
PubMed Central
by Yaghoobi-Ershadi, Mohammad Reza; Shahbazi, Farideh; Darvishi, Mohammad; Akhavan, Amir Ahmad; Jafari, Reza; Khajeian, Mohammad; Rassi, Yavar; Soleimani, Hassan; Shirzadi, Mohammad Reza; Hanafi-Bojd, Ahmad Ali; Darabi, Hossein; Arandian, Mohammad Hossein; Sanei-Dehkordi, Alireza; Heidari, Mansour
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This article is from Journal of Arthropod-Borne Diseases , volume 7 . Abstract Background: Cutaneous leishmaniasis (CL) represents the most frequent vector borne parasitoses in Iran. The objective of this study was to determine the epidemiological features of CL including human infection and the reservoir host in the city of Bushehr, Bushehr Province, Iran during 2010–2011. Methods:: Studies on human infection was carried out on 2962 school children aged 7–14 years old from 60 primary...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875877
PubMed Central
by Trevino, Mario; Aguilar-Garnica, Efren; Jendritza, Patrick; Li, Shi-Bin; Oviedo, Tatiana; Kohr, Georg; De Marco, Rodrigo J
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This article is from International Archives of Medicine , volume 4 . Abstract Background: In nature, sensory stimuli are organized in heterogeneous combinations. Salient items from these combinations 'stand-out' from their surroundings and determine what and how we learn. Yet, the relationship between varying stimulus salience and discrimination learning remains unclear. Presentation of the hypothesis: A rigorous formulation of the problem of discrimination learning should account for varying...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176477
PubMed Central
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This article is from Indian Journal of Endocrinology and Metabolism , volume 15 . Abstract Gonadotropin-releasing hormone (GnRH) agonists are derived from native GnRH by amino acid substitution which yields the agonist resistant to degradation and increases its half-life. The hypogonadotropic hypogonadal state produced by GnRH agonists has been often dubbed as “pseudomenopause” or “medical oophorectomy,” which are both misnomers. GnRH analogues (GnRH-a) work by temporarily “switching...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193774
PubMed Central
by Schneider, Britta; Grote, Michael; John, Matthias; Haas, Alexander; Bramlage, Birgit; lckenstein, Ludger M; Jahn-Hofmann, Kerstin; Bauss, Frieder; Cheng, Weijun; Croasdale, Rebecca; Daub, Karin; Dill, Simone; Hoffmann, Eike; Lau, Wilma; Burtscher, Helmut; Ludtke, James L; Metz, Silke; Mundigl, Olaf; Neal, Zane C; Scheuer, Werner; Stracke, Jan; Herweijer, Hans; Brinkmann, Ulrjch
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This article is from Molecular Therapy. Nucleic Acids , volume 1 . Abstract Bispecific antibodies (bsAbs) that bind to cell surface antigens and to digoxigenin (Dig) were used for targeted small interfering RNA (siRNA) delivery. They are derivatives of immunoglobulins G (IgGs) that bind tumor antigens, such as Her2, IGF1-R, CD22, and LeY, with stabilized Dig-binding variable domains fused to the C-terminal ends of the heavy chains. siRNA that was digoxigeninylated at its 3′end was bound in a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464882
PubMed Central
by Peng, Yan; Xie, Enyi; Zheng, Kai; Fredimoses, Mangaladoss; Yang, Xianwen; Zhou, Xuefeng; Wang, Yifei; Yang, Bin; Lin, Xiuping; Liu, Juan; Liu, Yonghong
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This article is from Marine Drugs , volume 11 . Abstract Sargassum naozhouense is a brown seaweed used in folk medicine and applied for thousands of years in Zhanjiang, Guangdong province, China. This study is the first time to investigate its chemical composition and antiviral activity. On the dry weight basis, this seaweed was constituted of ca. 35.18% ash, 11.20% protein, 1.06% lipid and 47.73% total carbohydrate, and the main carbohydrate was water-soluble polysaccharide. The protein...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564154
PubMed Central
by Foote, Christopher
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This article is from BMC Evolutionary Biology , volume 14 . Abstract Contributing reviewers: The editors of BMC Evolutionary Biology would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905664
PubMed Central
by Deng, Jian Xin; Cho, Hye Sun; Paul, Narayan Chandra; Lee, Hyang Burm; Yu, Seung Hun
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This article is from Mycobiology , volume 42 . Abstract We isolated and examined a new Alternaria sp., which causes leaf spots on Peucedanum japonicum in Korea, by using molecular and morphological methods. Phylogenetic analysis based on a combined internal transcribed spacer region analysis and two protein-coding genes (gpd and Alt a1) demonstrated that the causal fungus was most closely related to A. cinerariae and A. sonchi, and relevant to A. brassicae. However, conidial morphology...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004941
PubMed Central
by Russ, Heloisa Helena; Nogueira-Filho, Pedro Antonio; de Nadai Barros, Jeison; de Faria, Nubia Vanessa Lima; Montiani-Ferreira, Fabiano; Gomes, Jose Alvaro Pereira; Mello, Paulo Augusto Arruda
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This article is from Clinics , volume 68 . Abstract OBJECTIVES:: To compare ocular surface changes induced via glaucoma treatment in patients using fixed combinations of prostaglandin analogues (travoprost, latanoprost and bimatoprost) with 0.5% timolol maleate METHODS:: A prospective, multicenter, randomized, parallel group, single-blind clinical trial was performed in 33 patients with ocular hypertension or open angle glaucoma who had not been previously treated. The ocular surface was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798551
PubMed Central
by Zhang, Xiangxiang; Fang, Jianzheng; Xu, Bin; Zhang, Shengli; Su, Shifeng; Song, Zhen; Deng, Yunfei; Wang, Hainan; Zhao, Dan; Niu, Xiaobing; Wang, Zengjun
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This article is from PLoS ONE , volume 8 . Abstract Objective: Epididymal protease inhibitor (Eppin) was located on the surface of spermatozoa and modulates the liquefaction of human semen. Here, we identify the correlative protein partner of Eppin to explore the molecular mechanism of liquefaction of human semen. Methods: (1) Human seminal vesicle proteins were transferred on the membrane by Western blotting and separated by 2-D electrophoresis and incubated in recombinant Eppin. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865146
PubMed Central
by Cretu, Daniela; Prassas, Ioannis; Saraon, Punit; Batruch, Ihor; Gandhi, Rajiv; Diamandis, Eleftherios P; Chandran, Vinod
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This article is from Clinical Proteomics , volume 11 . Abstract Background: Synovial fluid (SF) is a dynamic reservoir for proteins originating from the synovial membrane, cartilage, and plasma, and may therefore reflect the pathophysiological conditions that give rise to arthritis. Our goal was to identify and quantify protein mediators of psoriatic arthritis (PsA) in SF. Methods: Age and gender-matched pooled SF samples from 10 PsA and 10 controls [early osteoarthritis (OA)], were subjected...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108225
PubMed Central
by Villoutreix, Bruno O; Kuenemann, Melaine A; Poyet, Jean-Luc; Bruzzoni-Giovanelli, Heriberto; Labbe, Celine; Lagorce, David; Sperandio, Olivier; Miteva, Maria A
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This article is from Molecular Informatics , volume 33 . Abstract Fundamental processes in living cells are largely controlled by macromolecular interactions and among them, protein–protein interactions (PPIs) have a critical role while their dysregulations can contribute to the pathogenesis of numerous diseases. Although PPIs were considered as attractive pharmaceutical targets already some years ago, they have been thus far largely unexploited for therapeutic interventions with low...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160817
PubMed Central
by Navabi, N; Nakhaee, N; Mirzadeh, A
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This article is from Iranian Journal of Public Health , volume 39 . Abstract Background:: The oral health-related quality of life indicators are increasingly used to measure the impact of the oral conditions on quality of life. One of the most used indicators is the Oral Health Impact Profile (OHIP-14), but it has never been applied in Iran. The aim of this study was to validate the usage of OHIP-14 among Iranians. Methods:: A cross-sectional study was performed in Kerman (Iran). A consecutive...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481693
PubMed Central
by Morawska, Magdalena
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This article is from BMC Gastroenterology , volume 14 . Abstract Contributing reviewers: The editors of BMC Gastroenterology would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898228
PubMed Central
by Gali, Himabindu; Juhasz, Szilvia; Morocz, Monika; Hajdu, Ildiko; Fatyol, Karoly; Szukacsov, Valeria; Burkovics, Peter; Haracska, Lajos
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This article is from Nucleic Acids Research , volume 40 . Abstract DNA double-strand breaks (DSBs) can be generated not only by reactive agents but also as a result of replication fork collapse at unrepaired DNA lesions. Whereas ubiquitylation of proliferating cell nuclear antigen (PCNA) facilitates damage bypass, modification of yeast PCNA by small ubiquitin-like modifier (SUMO) controls recombination by providing access for the Srs2 helicase to disrupt Rad51 nucleoprotein filaments. However,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401441
PubMed Central
by Peng, Shiqiu; Qian, Yu-Kun; Lai, Zhijuan; Hao, Sai; Chen, Shumin; Xu, Hongxiong; Wang, Dongxiao; Xu, Xiangde; Chan, Johnny C. L.; Zhou, Hao; Liu, Duanling
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This article is from Scientific Reports , volume 4 . Abstract Tropical cyclones (TC) are one of the most threatening natural hazards to human beings. Although significant improvements have been made in the track prediction of TCs during the past several decades, considerable uncertainties still exist, especially for recurving tracks. In this study, we explore the physical mechanisms that drove the large recurvature of super typhoon Megi through numerical sensitivity experiments using a regional...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964559
PubMed Central
by HARA, MARINA; KURODA, MASAHIRO; OHMURA, YUICHI; MATSUZAKI, HIDENOBU; KOBAYASHI, TOMOKI; MURAKAMI, JUN; KATASHIMA, KAZUNORI; ASHIDA, MASAKAZU; OHNO, SEIICHIRO; ASAUMI, JUN-ICHI
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This article is from Oncology Letters , volume 8 . Abstract The aim of this study was to create a new phantom for a 3 Tesla (3T) magnetic resonance imaging (MRI) device for the calculation of the apparent diffusion coefficient (ADC) using diffusion-weighted imaging (DWI), and to mimic the ADC values of normal and tumor tissues at various temperatures, including the physiological body temperature of 37°C. The phantom was produced using several concentrations of sucrose from 0 to 1.2 M, and the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081373
PubMed Central
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This article is from BMC Public Health , volume 12 . Abstract Background: Cases of polio in India declined after the implementation of the polio eradication programme especially in these recent years. The programme includes surveillance of acute flaccid paralysis (AFP) to detect and diagnose cases of polio at early stage. Under this surveillance, over 40,000 cases of AFP are reported annually since 2007 regardless of the number of actual polio cases. Yet, not much is known about these children....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331818
PubMed Central
by Mishra, Ajay Kumar; Hugon, Perrine; Lagier, Jean-Christophe; Nguyen, Thi-Thien; Robert, Catherine; Couderc, Carine; Raoult, Didier; Fournier, Pierre-Edouard
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This article is from Standards in Genomic Sciences , volume 7 . Abstract Peptoniphilus obesi strain ph1T sp. nov., is the type strain of P. obesi sp. nov., a new species within the genus Peptoniphilus. This strain, whose genome is described here, was isolated from the fecal flora of a 26-year-old woman suffering from morbid obesity. P. obesi strain ph1T is a Gram-positive, obligate anaerobic coccus. Here we describe the features of this organism, together with the complete genome sequence and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764929
PubMed Central
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This article is from Annals of Oncology , volume 25 . Abstract In this multinational, phase III study, the safety and efficacy of NEPA, a convenient, fixed-dose antiemetic combination of netupitant, a highly selective NK1 receptor antagonist (RA), and palonosetron, a distinct 5-HT3 RA, were evaluated over multiple cycles of highly and moderately emetogenic chemotherapy. NEPA was shown to be safe, well tolerated and highly effective over 1961 chemotherapy cycles.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071753
PubMed Central
by Saxena, Anjali; Kumari, Rashmi; Mukherjee, Udita; Singh, Priya; Lal, Rup
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This article is from Genome Announcements , volume 2 . Abstract Amycolatopsis rifamycinica DSM 46095 is an actinobacterium that produces rifamycin SV, an antibiotic used against Mycobacterium tuberculosis. Here, we present the draft genome of DSM 46095, which harbors a novel rifamycin polyketide biosynthetic gene cluster (rif PKS) that differed by 10% in nucleotide sequence from the already reported rif PKS cluster of Amycolatopsis mediterranei S699.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082003
PubMed Central
by Charnay, Yves; Leger, Lucienne
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This article is from Dialogues in Clinical Neuroscience , volume 12 . Abstract Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) plays a modulatory role in almost every physiological function. Furthermore, serotonergic dysfunction is thought to be implicated in several psychiatric and neurodegenerative disorders. We describe the neuroanatomy and neurochemistry of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181988
PubMed Central
by Liu, Xiang-hua; Lu, Kai-hua; Wang, Ke-ming; Sun, Ming; Zhang, Er-bao; Yang, Jin-song; Yin, Dan-dan; Liu, Zhi-li; Zhou, Jing; Liu, Zhi-jun; De, Wei; Wang, Zhao-xia
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This article is from BMC Cancer , volume 12 . Abstract Background: MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated in several other cancers, its role in non-small cell lung cancer (NSCLC) is unknown. The aim of the present study was to examine the expression pattern of miR-196a in NSCLC and its clinical significance, as well as its biological...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503718
PubMed Central
by Majithia, Deesha A
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This article is from BMC Neuroscience , volume 14 . Abstract Contributing reviewers: The editors of BMC Neuroscience would like to thank all our reviewers who have contributed to the journal in Volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626905
PubMed Central
by Finkenwirth, Friedrich; Kirsch, Franziska; Eitinger, Thomas
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This article is from Bioengineered , volume 5 . Abstract Biotin is an essential cofactor of carboxylase enzymes in all kingdoms of life. The vitamin is produced by many prokaryotes, certain fungi, and plants. Animals depend on biotin uptake from their diet and in humans lack of the vitamin is associated with serious disorders. Many aspects of biotin metabolism, uptake, and intracellular transport remain to be elucidated. In order to characterize the activity of novel biotin transporters by a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049904
PubMed Central
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This article is from United European Gastroenterology Journal , volume 1 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070608
PubMed Central
by Liu, Yunqiang; Wang, Meiling; Jiang, Siyuan; Lu, Yongjie; Tao, Dachang; Yang, Yuan; Ma, Yongxin; Zhang, Sizhong
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This article is from BMB Reports , volume 47 . Abstract Tissue-specific gene expression is regulated by epigenetic modification involving trans-acting factors. Here, we identified that the human MAGEB16 gene and its mouse homolog, Mageb16, are only expressed in the testis. To investigate the mechanism governing their expression, the promoter methylation status of these genes was examined in different samples. Two CpG islands (CGIs) in the 5' upstream region of MAGEB16 were highly demethylated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163901
PubMed Central
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This article is from Trials , volume 14 . Abstract Background: Prevalence of exercise-induced bronchoconstriction (EIB) is high in elite athletes, especially after many years training in cold and dry air conditions. The primary treatment of EIB is inhaling a short-acting beta-2-agonist such as salbutamol. However, professional speed skaters also inhale nebulized isotonic saline or tap water before and after a race or intense training. The use of nebulized isotonic saline or tap water to prevent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710477
PubMed Central
by Powikrowska, Marta; Oetke, Svenja; Jensen, Poul E.; Krupinska, Karin
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This article is from Frontiers in Plant Science , volume 5 . Abstract In this article recent progress on the elucidation of the dynamic composition and structure of plastid nucleoids is reviewed from a structural perspective. Plastid nucleoids are compact structures of multiple copies of different forms of ptDNA, RNA, enzymes for replication and gene expression as well as DNA binding proteins. Although early electron microscopy suggested that plastid DNA is almost free of proteins, it is now...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154389
PubMed Central
by Relogio, Angela; Thomas, Philippe; Medina-Perez, Paula; Reischl, Silke; Bervoets, Sander; Gloc, Ewa; Riemer, Pamela; Mang-Fatehi, Shila; Maier, Bert; Schafer, Reinhold; Leser, Ulf; Herzel, Hanspeter; Kramer, Achim; Sers, Christine
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This article is from PLoS Genetics , volume 10 . Abstract Circadian rhythms are essential to the temporal regulation of molecular processes in living systems and as such to life itself. Deregulation of these rhythms leads to failures in biological processes and eventually to the manifestation of pathological phenotypes including cancer. To address the questions as to what are the elicitors of a disrupted clock in cancer, we applied a systems biology approach to correlate experimental,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038477
PubMed Central
by Seinfeld, Sofia; Figueroa, Heidi; Ortiz-Gil, Jordi; Sanchez-Vives, Maria V.
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This article is from Frontiers in Psychology , volume 4 . Abstract Reading music and playing a musical instrument is a complex activity that comprises motor and multisensory (auditory, visual, and somatosensory) integration in a unique way. Music has also a well-known impact on the emotional state, while it can be a motivating activity. For those reasons, musical training has become a useful framework to study brain plasticity. Our aim was to study the specific effects of musical training vs....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814522
PubMed Central
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This article is from BMC Infectious Diseases , volume 14 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080250
PubMed Central
by Casadevall, Arturo
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This article is from mBio , volume 5 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128361
PubMed Central
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This article is from Yonsei Medical Journal , volume 53 . Abstract Purpose: The purpose of this study was to compare postoperative range of motion and functional outcomes among patients who received high-flexion total knee arthroplasty using cruciate-retaining (CR-Flex) and posterior-stabilized (PS-Flex) type prostheses. Materials and Methods: Among 127 patients (186 knees) who underwent high-flexion total knee arthroplasty between 2005 and 2007, 92 knees were placed in the CR-Flex group, and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381472
PubMed Central
by Moussa, Syrine Ben; Sfaxi, Ines; Tabka, Zouhair; Saad, Helmi Ben; Rouatbi, Sonia
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This article is from The Libyan Journal of Medicine , volume 9 . Abstract Background: The mechanisms of smoking tobacco leading to chronic obstructive pulmonary disease (COPD) are beginning to be understood. However, conclusions about the role of blood or lung oxidative stress markers were disparate. Aims: To investigate the oxidative stress in blood or lung associated with tobacco smoke and to evaluate its effect on pulmonary function data and its relation with physical activity. Methods: It...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057786
PubMed Central
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This article is from Diabetes, Obesity & Metabolism , volume 15 . Abstract Aim: Assess the pharmacodynamics of lixisenatide once daily (QD) versus liraglutide QD in type 2 diabetes insufficiently controlled on metformin. Methods: In this 28-day, randomized, open-label, parallel-group, multicentre study (NCT01175473), patients (mean HbA1c 7.3%) received subcutaneous lixisenatide QD (10 µg weeks 1–2, then 20 µg; n = 77) or liraglutide QD (0.6 mg week 1, 1.2 mg week 2, then 1.8 mg; n = 71)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752965
PubMed Central
by Jung, Yoon Suk; Seok, Hyo Sun; Park, Dong Il; Song, Chang Seok; Kim, Seong Eun; Lee, Suck Ho; Eun, Chang Soo; Han, Dong Soo; Kim, Yong Soo; Lee, Chang Kyun
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This article is from Gut and Liver , volume 7 . Abstract Background/Aims: A dietary regimen consisting of a clear liquid diet (CLD) for at least 24 hours is recommended for colonoscopy preparation. However, this requirement results in problems in patient compliance with bowel preparation. The aim of this study was to evaluate the efficacy of a CLD compared with a regular diet (RD) for colonoscopy preparation using a polyethylene glycol (PEG) solution. Methods: This was a multicenter,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848543
PubMed Central
by Obata, Toshihiro; Schoenefeld, Steffi; Krahnert, Ina; Bergmann, Susan; Scheffel, Andre; Fernie, Alisdair R.
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This article is from Metabolites , volume 3 . Abstract Algae are divergent organisms having a wide variety of evolutional histories. Although most of them share photosynthetic activity, their pathways of primary carbon metabolism are rather diverse among species. Here we developed a method for gas chromatography-mass spectroscopy (GC-MS) based metabolite profiling for the coccolithophorid alga Emiliania huxleyi, which is one of the most abundant microalgae in the ocean, in order to gain an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901260
PubMed Central
by Yen, Chi-Hung; Ho, Pak-Cheong; Hung, Leung-Kim
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This article is from Journal of Orthopaedic Surgery and Research , volume 7 . Abstract Surgery for thumb polydactyly is a commonly performed orthopaedic procedure in Asia Pacific region. Despite extensive publications on topical dressing methods and dressing materials in paediatric wounds, there is no single design that affords a secure and yet comfortable post-operative wound dressing for thumb polydactyly. We have devised a new dressing method, which can easily be fabricated for such purpose...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413560
PubMed Central
by Rice, Catherine M
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This article is from BMC Genomics , volume 14 . Abstract Contributing reviewers: The editors of BMC Genomics would like to thank all our reviewers who have contributed to the journal in volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642022
PubMed Central
by Hommel, Marcel
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This article is from Malaria Journal , volume 13 . Abstract Contributing reviewers: Malaria Journal would like to thank all reviewers who have contributed to the journal in 2013.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917501
PubMed Central
by Krupinska, Karin; Oetke, Svenja; Desel, Christine; Mulisch, Maria; Schafer, Anke; Hollmann, Julien; Kumlehn, Jochen; Hensel, Gotz
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This article is from Frontiers in Plant Science , volume 5 . Abstract WHIRLY1 is an abundant protein of chloroplast nucleoids, which has also been named pTAC-1 with regard to its detection in the proteome of transcriptionally active chromosomes (TAC). In barley primary foliage leaves, expression of the WHIRLY1 gene is highest at the base whereas protein accumulation is highest in the middle of the leaf where young developing chloroplasts are found. In order to elucidate the function of WHIRLY1...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154442
PubMed Central
by Khodadad, Ahmad; Modaresi, Vajiheh; Kiani, Mohammad-Ali; Rabani, Ali; Pakseresht, Bahar
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This article is from Iranian Journal of Pediatrics , volume 21 . Abstract Background: Lipoid congenital adrenal hyperplasia, is the rarest and usually the most severe form of adrenal steroidogenic defect,which may presents as infantile cholestasis. Case Presentation: Here we present a 45 days old infant who came to our attention with cholestasis and severe intractable vomiting and electrolyte disturbances. Evaluation resulted in diagnosis of congenital adrenal hyperplasia. Hydrocortisone and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446141
PubMed Central
by Arme, Chris
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This article is from Parasites & Vectors , volume 6 . Abstract Contributing reviewers: Parasites & Vectors would like to thank the following for their assistance with peer review of manuscripts for the journal in 2012.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601990
PubMed Central
by Godin, Konstantin; Bang, Nicole; Tolkach, Yuri
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This article is from F1000Research , volume 3 . Abstract The clinical case of a 65-year-old woman with an incidentally detected left-sided mass in the upper renal pole is presented. A functional adrenal tumor was excluded. The mass was removed retroperitoneoscopically. The perioperative period was uneventful. The histopathological examination revealed a heterotopic intrarenal adrenocortical oncocytoma.Adrenal oncocytic neoplasms are very rare, with, to the authors’ knowledge, only 159...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168838
PubMed Central
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This article is from Journal of Cardiovascular and Thoracic Research , volume 6 . Abstract Acute myocardial infarction (AMI) is a life threatening condition that needs emergency diagnosis and early treatment in the emergency room. Rapid laboratory testing for creatine kinase (CK)-MB greatly revolutionized the diagnosis and management of acute myocardial infarction. We report a case with chest pain that referred to the emergency department (ED). Laboratory data showed high serum levels of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992737