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PubMed Central is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM).


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Dec 30, 2014 Sharma, Malay; Adulqader, Almessabi; Shifa, Ruth
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This article is from Endoscopic Ultrasound , volume 3 . Abstract Lower gastrointestinal (GI) bleed due to hemangioma in rectum is an uncommon problem. A 19-year-old female patient presented with history of recurrent episodes of lower GI bleeding 1-2 times/month for last 3 years. At the time of hospitalization her vital signs were normal and rectal examination revealed frank blood. Investigations revealed a hemoglobin level of 8.9 g/dL and normal coagulation parameters. Colonoscopy showed bluish...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063266
PubMed Central
Dec 18, 2014 Kaul, Rudra; Kaul, Vibhuti; Farooq, Riyaz; Wazir, Nikhil Dev; Khateeb, Shafayat Ullah; Malik, Altaf H; Masoodi, Ajaz Amin
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This article is from Journal of Conservative Dentistry : JCD , volume 17 . Abstract Aims:: The aim of the following study is to evaluate the change in laser fluorescence (LF) values for extracted teeth stored in different solutions over 1 year period, to give cut-off values for different storage media at different time intervals to get them at par with the in vivo conditions and to see which medium gives best results with the least change in LF values and while enhancing the validity of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001266
PubMed Central
Nov 22, 2014 Ajami, Sima; Arzani-Birgani, Arezo
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This article is from Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences , volume 19 . Abstract Background:: In Iran, burns are the second most common cause of death, after traffic accidents in individuals under the age of 15 years. Many burned patients die or suffer injury due to lack of immediate care, so we need to use an alternative resuscitations to cure them immediately. Telemedicine describes the use of medical information exchanged...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155713
PubMed Central
Nov 6, 2014 de Rezende, Marcia Uchoa; Hernandez, Arnaldo Jose; Camanho, Gilberto Luis
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This article is from Acta Ortopedica Brasileira , volume 22 . Abstract OBJECTIVE:: To analyze the anteroposterior displacement of the knee by means of stress radiography in individuals with unilateral anterior knee instability and relate to time of instability. METHODS:: Sixty individuals with intact knees (control group) and 125 patients with unilateral anterior instability (AI group) agreed to participate in the study. Gender, age, weight, height, age at injury, time between injury and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167040
PubMed Central
Oct 30, 2014 Burke, Russell T; Meadows, Sarah; Loriaux, Marc M; Currie, Kevin S.; Mitchell, Scott A.; Maciejewski, Patricia; Clarke, Astrid S.; Dipaolo, Julie A.; Druker, Brian J.; Lannutti, Brian J.; Spurgeon, Stephen E.
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This article is from Oncotarget , volume 5 . Abstract Agents that target B-cell receptor (BCR) signaling in lymphoid malignancies including idelalisib (GS-1101) and fostamatinib which inhibit the delta isoform of PI3 kinase (PI3Kd) and spleen tyrosine kinase (Syk) respectively have shown significant clinical activity. By disrupting B-cell signaling pathways, idelalisib treatment has been associated with a dramatic lymph node response, but eradication of disease and relapse in high risk disease...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011593
PubMed Central
Oct 27, 2014 Vafaeenasab, Mohammad Reza; Ghasemi, Nasrin; Mahmoodi, Samaneh; Ghasemi, Fatemeh
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This article is from Iranian Journal of Medical Sciences , volume 39 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100054
PubMed Central
Oct 24, 2014 Belalcazar, Andrea D.; Ball, John G.; Frost, Leslie M.; Valentovic, Monica A.; Wilkinson, John
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This article is from ISRN biochemistry , volume 2013 . Abstract The transsulfuration pathway, through which homocysteine from the methionine cycle provides sulfur for cystathionine formation, which may subsequently be used for glutathione synthesis, has not heretofore been identified as active in mammary cells. Primary human mammary epithelial cells (HMEC’s) were labeled with 35S-methionine for 24 hours following pretreatment with a vehicle control, the cysteine biosynthesis inhibitor...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949734
PubMed Central
Oct 23, 2014 Libraty, Daniel H.; Zhang, Lei; Woda, Marcia; Acosta, Luz P.; Obcena, AnaMae; Brion, Job D.; Capeding, Rosario Z.
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This article is from Trials in vaccinology , volume 3 . Abstract Neonatal Bacille Calmette Guérin (BCG) vaccination has been reported to have beneficial effects beyond preventing infantile tuberculous meningitis and miliary disease. We hypothesized that BCG vaccine given at birth would enhance T-helper 1 (Th1) immune responses to the first vaccines given later in infancy. We conducted a nested case-control study of neonatal BCG vaccination and its heterologous Th1 immune effects in 2–3...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943168
PubMed Central
Oct 22, 2014 Prasad, Rahul M.; Jin, Xingjian; Nauli, Surya M.
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This article is from Biosensors , volume 4 . Abstract Over the past decade, primary cilia have emerged as the premier means by which cells sense and transduce mechanical stimuli. Primary cilia are sensory organelles that have been shown to be vitally involved in the mechanosensation of urine in the renal nephron, bile in the hepatic biliary system, digestive fluid in the pancreatic duct, dentin in dental pulp, lacunocanalicular fluid in bone and cartilage, and blood in vasculature. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019930
PubMed Central
Oct 7, 2014 Rabiee, Seyed Mozaffar; Alijanpour, Ebrahim; Jabbari, Ali; Rostami, Sara
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This article is from Caspian Journal of Internal Medicine , volume 5 . Abstract Background: General anesthesia draws attention to the most commonly used modalities for post cesarean delivery pain relief in systemic administration of opioids, while the administration of small dose of intrathecal opioid during spinal anesthesia can be a possible alternative. The aim of this study was to evaluate the effects of buprenorphine on cesarean section prescribed intrathecally.Methods: This double blind...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143735
PubMed Central
Sep 28, 2014 Rahpeyma, Amin; Khajehahmadi, Saeedeh
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This article is from Iranian Journal of Otorhinolaryngology , volume 26 . Abstract Introduction:: The horizontal bony canal in the lateral maxillary wall is the site of anastomosis between the arterial branches from the posterior superior alveolar artery (PSAa) and the infraorbital artery. This anatomic structure is known as the ‘alveolar antral artery’. Materials and Methods:: We performed a literature review. The anatomic location of the alveolar antral artery in the lateral maxillary...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989871
PubMed Central
Sep 24, 2014 Lippold, Sebastian; Xu, Hongyang; Ko, Albert; Li, Mingkun; Renaud, Gabriel; Butthof, Anne; Schroder, Roland; Stoneking, Mark
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This article is from Investigative Genetics , volume 5 . Abstract Background: Comparisons of maternally-inherited mitochondrial DNA (mtDNA) and paternally-inherited non-recombining Y chromosome (NRY) variation have provided important insights into the impact of sex-biased processes (such as migration, residence pattern, and so on) on human genetic variation. However, such comparisons have been limited by the different molecular methods typically used to assay mtDNA and NRY variation (for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174254
PubMed Central
Sep 23, 2014 Li, Jun; Guan, Xiaotao; Shaw, Neil; Chen, Weimin; Dong, Yu; Xu, Xiaoling; Li, Xuemei; Rao, Zihe
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This article is from Scientific Reports , volume 4 . Abstract Mycobacterium tuberculosis (Mtb) uses maltose-1-phosphate to synthesize α-glucans that make up the major component of its outer capsular layer. Maltose kinase (MaK) catalyzes phosphorylation of maltose. The molecular basis for this phosphorylation is currently not understood. Here, we describe the first crystal structure of MtbMaK refined to 2.4 Å resolution. The bi-modular architecture of MtbMaK reveals a remarkably unique...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171701
PubMed Central
Sep 23, 2014 Zhang, J.; Liu, H. J.; Cheng, L.; Wei, J.; Liang, J. H.; Fan, D. D.; Shi, J.; Tang, X. F.; Zhang, Q. J.
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This article is from Scientific Reports , volume 4 . Abstract In this work, the electronic properties of phosphorene nanoribbons with different width and edge configurations are studied by using density functional theory. It is found that the armchair phosphorene nanoribbons are semiconducting while the zigzag nanoribbons are metallic. The band gaps of armchair nanoribbons decrease monotonically with increasing ribbon width. By passivating the edge phosphorus atoms with hydrogen, the zigzag...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171703
PubMed Central
Sep 23, 2014 Xu, Zhemi; Ao, Zhimin; Chu, Dewei; Younis, Adnan; Li, Chang Ming; Li, Sean
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This article is from Scientific Reports , volume 4 . Abstract Although the reversible wettability transition between hydrophobic and hydrophilic graphene under ultraviolet (UV) irradiation has been observed, the mechanism for this phenomenon remains unclear. In this work, experimental and theoretical investigations demonstrate that the H2O molecules are split into hydrogen and hydroxyl radicals, which are then captured by the graphene surface through chemical binding in an ambient environment...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171696
PubMed Central
Sep 23, 2014 Destek, Sebahattin; Gul, Vahit Onur; Ahioglu, Serkan; Tatar, Zeynep; Erbil, Yesim
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This article is from Journal of Surgical Case Reports , volume 2014 . Abstract Eosinophilic esophagitis (EE) is attributable to environmental factors, allergens and several immunological causes. The most typical symptoms include dysphagia and sensation of food impingement in the retrosternal area. Although its clinical features resemble those of gastroesophageal reflux, proton pump inhibitors are not effective for its treatment. The diagnosis of EE is dependent on the pathological detection of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171690
PubMed Central
Sep 23, 2014 Hung, Chao-Ming; Chang, Chi-Chang; Lin, Chen-Wei; Chen, Chih-Chen; Hsu, Yi-Chiang
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This article is from Scientific Reports , volume 4 . Abstract Nasopharyngeal carcinoma (NPC) is a common form of malignant cancer, for which radiotherapy or chemotherapy are the main treatment methods. Cucurbitacin E (CuE) is a natural compound-based drug which from the climbing stem of Cucumic melo L (Guadi). Previously shown to be an antifeedant as well as a potent chemopreventive agent against several types of cancer. The present study, investigated anti-proliferation and cell cycle G2/M...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171705
PubMed Central
Sep 23, 2014 Lim, Seul Ye; Ahn, So-Hee; Park, Hyunju; Lee, Jungsul; Choi, Kyungsun; Choi, Chulhee; Choi, Ji Ha; Park, Eun-Mi; Choi, Youn-Hee
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This article is from Scientific Reports , volume 4 . Abstract Adrenomedullin (ADM), a secretory peptide with multiple functions in physiological to pathological conditions, is upregulated in several human cancers, including brain, breast, colon, prostate, and lung cancer. However, the molecular mechanisms underlying the regulation of ADM expression in cancerous cells are not fully understood. Here, we report that oncostatin M (OSM), a cytokine belonging to the interleukin-6 family, induces ADM...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171698
PubMed Central
Sep 23, 2014 Sun, Yu; Liang, Yuan; Hu, Jinlong; Wang, Jingcheng; Wang, Daxin; Li, Xiaolei; Yan, Lianqi
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This article is from Scientific Reports , volume 4 . Abstract The aim of this study was to investigate the efficacy of topical application of colchicine in reducing intraarticular adhesion in rabbits. Thirty-six rabbits were randomly and equally divided into three groups. An approximately 10 × 10 mm2 area of cortical bone was removed from both sides of the left femoral condyle, and the cancellous bone underneath was exposed. Cotton pads soaked with different concentrations of colchicine or...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171695
PubMed Central
Sep 23, 2014 Nohara, Chiyo; Taira, Wataru; Hiyama, Atsuki; Tanahara, Akira; Takatsuji, Toshihiro; Otaki, Joji M
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This article is from BMC Evolutionary Biology , volume 14 . Abstract Background: The release of radioactive materials due to the Fukushima nuclear accident has raised concern regarding the biological impacts of ingesting radioactively contaminated diets on organisms. We previously performed an internal exposure experiment in which contaminated leaves collected from polluted areas were fed to larvae of the pale grass blue butterfly, Zizeeria maha, from Okinawa, which is one of the least polluted...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171559
PubMed Central
Sep 23, 2014 Gori, Simone; Agrillo, Christian; Dadda, Marco; Bisazza, Angelo
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This article is from Scientific Reports , volume 4 . Abstract Motion illusion refers to a perception of motion that is absent or different in the physical stimulus. These illusions are a powerful non-invasive tool for understanding the neurobiology of vision because they tell us, indirectly, how we process motion. There is general agreement in ascribing motion illusion to higher-level processing in the visual cortex, but debate remains about the exact role of eye movements and cortical networks...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171700
PubMed Central
Sep 23, 2014 Huang, Bin; Lu, Mingyang; Jolly, Mohit Kumar; Tsarfaty, Ilan; Onuchic, Jose; Ben-Jacob, Eshel
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This article is from Scientific Reports , volume 4 . Abstract Metastatic carcinoma cells exhibit at least two different phenotypes of motility and invasion - amoeboid and mesenchymal. This plasticity poses a major clinical challenge for treating metastasis, while its underlying mechanisms remain enigmatic. Transitions between these phenotypes are mediated by the Rac1/RhoA circuit that responds to external signals such as HGF/SF via c-MET pathway. Using detailed modeling of GTPase-based...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171704
PubMed Central
Sep 23, 2014 Galiveti, Chenna R.; Raabe, Carsten A.; Konthur, Zoltan; Rozhdestvensky, Timofey S.
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This article is from Scientific Reports , volume 4 . Abstract Prader-Willi Syndrome (PWS) is a neurogenetic disorder caused by the deletion of imprinted genes on the paternally inherited human chromosome 15q11-q13. This locus harbours a long non-protein-coding RNA (U-UBE3A-ATS) that contains six intron-encoded snoRNAs, including the SNORD116 and SNORD115 repetitive clusters. The 3′-region of U-UBE3A-ATS is transcribed in the cis-antisense direction to the ubiquitin-protein ligase E3A (UBE3A)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171697
PubMed Central
Sep 23, 2014 Guo, Min; Xie, Keyu; Wang, Yu; Zhou, Limin; Huang, Haitao
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This article is from Scientific Reports , volume 4 . Abstract Bandgap engineering of a photonic crystal is highly desirable for photon management in photonic sensors and devices. Aperiodic photonic crystals (APCs) can provide unprecedented opportunities for much more versatile photon management, due to increased degrees of freedom in the design and the unique properties brought about by the aperiodic structures as compared to their periodic counterparts. However, many efforts still remain on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171702
PubMed Central
Sep 23, 2014 Dhar, Harsh; Dabholkar, Jyoti P.; Kandalkar, Bhuwaneshwari M.; Ghodke, Ratnaprabha
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This article is from Journal of Surgical Case Reports , volume 2014 . Abstract The thyroid gland is a very rare site for head and neck schwannomas. Till date there have been only 19 reported cases in English literature. Only 25% of schwannomas occur in the head and neck region, most of them arising in relation to the peripheral nerves and cervical sympathetic chain. We report a similar case, with clinical and sonological features of a benign thyroid nodule. The diagnosis of schwannoma was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171691
PubMed Central
Sep 22, 2014 de Moraes Soares, Celina M P; Vergara, Tania R C; Brites, Carlos; Brito, Jose D U; Grinberg, Gorki; Caseiro, Marcos M; Correa, Carlos; Suffert, Theodoro A; Pereira, Flavio R; Camargo, Michelle; Janini, Luiz M; Komninakis, Shirley; Sucupira, Maria C A; Diaz, Ricardo S
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This article is from Journal of the International AIDS Society , volume 17 . Abstract Introduction: In Brazil, the use of antiretrovirals is widespread: more than 260,000 individuals are currently undergoing treatment. We conducted a survey targeting antiretroviral-naïve individuals who were initiating antiretroviral therapy (ART) according to local guidelines. This survey covered five Brazilian regions. Methods: The HIV Threshold Survey methodology (HIV-THS) of the World Health Organization...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172689
PubMed Central
Sep 22, 2014 Dodd, Jodie M; O'Brien, Cecelia; Grivell, Rosalie M
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This article is from BMC Medicine , volume 12 . Abstract Pre-eclampsia is a common pregnancy related condition, which contributes significantly both to maternal and perinatal morbidity and mortality. The precise pathophysiology of pre-eclampsia is uncertain, and the development of effective preventive strategies remains elusive.Schoenaker and colleagues conducted a systematic review and meta-analysis of observational studies reporting dietary intake and dietary patterns. The findings indicated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171580
PubMed Central
Sep 22, 2014 Li, Xiaolin; Fang, Evandro Fei; Scheibye-Knudsen, Morten; Cui, Honghua; Qiu, Lu; Li, Jian; He, Yuping; Huang, Jing; Bohr, Vilhelm A.; Ng, Tzi Bun; Guo, Hongwei
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This article is from Scientific Reports , volume 4 . Abstract Di-(2-ethylhexyl)-phthalate (DEHP) is a ubiquitously used endocrine disruptor.There is widespread exposure to DEHP in the general population which has raised substantial public concern due to its potential detrimental health effects. It is particularly pertinent to investigate the molecular mechanisms of its testicular toxicity which are largely unknown. By feeding male rats DEHP for 2 weeks, rat spermatogenesis became disrupted,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170195
PubMed Central
Sep 22, 2014 Li, Bin; Huang, Guiqin; Sun, Jian; Xing, Zhongwen
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This article is from Scientific Reports , volume 4 . Abstract Transition metal selenide and telluride have recently receive considerable attention due to their possible structural relation to ferropnictide. Pressure is often used as an efficient way to modify the crystal or electronic structure that in many cases lead to new material states of interest. Here we search the structures of IrTe2 up to 150 GPa using crystal structure prediction techniques combining with ab initio calculations....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170196
PubMed Central
Sep 22, 2014 Sabin, Carlos; White, Angela; Hackermuller, Lucia; Fuentes, Ivette
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This article is from Scientific Reports , volume 4 . Abstract We introduce a primary thermometer which measures the temperature of a Bose-Einstein Condensate in the sub-nK regime. We show, using quantum Fisher information, that the precision of our technique improves the state-of-the-art in thermometry in the sub-nK regime. The temperature of the condensate is mapped onto the quantum phase of an atomic dot that interacts with the system for short times. We show that the highest precision is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170192
PubMed Central
Sep 22, 2014 Wang, Guirong; Zhang, Tao; Li, Xiaowen; Jiang, Zhiben; Jiang, Qian; Chen, Quanjiao; Tu, Xiaobin; Chen, Ze; Chang, Jianyu; Li, Laixing; Xu, Bing
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This article is from Scientific Reports , volume 4 . Abstract Extensive surveillance of influenza A viruses in different avian species is critical for understanding its transmission. Here, a breeding colony of Little Egrets and Black-crowned Night Herons was monitored both serologically and virologically in a city park of Jiangxi in 2009. A portion of herons had antibodies against H7 (52%), H5 (55%) and H9 (6%) subtype avian influenza virus (AIV) in egg yolk samples, and 45% had antibodies...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170210
PubMed Central
Sep 22, 2014 Dominguez, Antonia A.; Chiang, H. Rosaria; Sukhwani, Meena; Orwig, Kyle E.; Reijo Pera, Renee A.
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This article is from Scientific Reports , volume 4 . Abstract Turner syndrome is caused by complete or partial loss of the second sex chromosome and is characterized by spontaneous fetal loss in >90% of conceptions. Survivors possess an array of somatic and germline clinical characteristics. Induced pluripotent stem cells (iPSCs) offer an opportunity for insight into genetic requirements of the X chromosome linked to Turner syndrome. We derived iPSCs from Turner syndrome and control...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170197
PubMed Central
Sep 22, 2014 Vreeburg, Robert A. M.; Airianah, Othman B.; Fry, Stephen C.
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This article is from Biochemical Journal , volume 463 . Abstract Hydroxyl radicals (•OH) cause non-enzymic scission of polysaccharides in diverse biological systems. Such reactions can be detrimental (e.g. causing rheumatic and arthritic diseases in mammals) or beneficial (e.g. promoting the softening of ripening fruit, and biomass saccharification). Here we present a method for documenting •OH action, based on fluorescent labelling of the oxo groups that are introduced as glycosulose...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170706
PubMed Central
Sep 22, 2014 Du, Shangfeng; Lin, Kaijie; Malladi, Sairam K.; Lu, Yaxiang; Sun, Shuhui; Xu, Qiang; Steinberger-Wilckens, Robert; Dong, Hanshan
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This article is from Scientific Reports , volume 4 . Abstract In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support surface, significantly promoting the uniform growth of tiny Pt nuclei which directs the growth of ultrathin single-crystal Pt nanowire...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170194
PubMed Central
Sep 22, 2014 Rajasekharan, Ranjith; Balaur, Eugeniu; Minovich, Alexander; Collins, Sean; James, Timothy D.; Djalalian-Assl, Amir; Ganesan, Kumaravelu; Tomljenovic-Hanic, Snjezana; Kandasamy, Sasikaran; Skafidas, Efstratios; Neshev, Dragomir N.; Mulvaney, Paul; Roberts, Ann; Prawer, Steven
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This article is from Scientific Reports , volume 4 . Abstract The pixel size imposes a fundamental limit on the amount of information that can be displayed or recorded on a sensor. Thus, there is strong motivation to reduce the pixel size down to the nanometre scale. Nanometre colour pixels cannot be fabricated by simply downscaling current pixels due to colour cross talk and diffraction caused by dyes or pigments used as colour filters. Colour filters based on plasmonic effects can overcome...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170198
PubMed Central
Sep 22, 2014 Fadil, Ahmed; Iida, Daisuke; Chen, Yuntian; Ma, Jun; Ou, Yiyu; Petersen, Paul Michael; Ou, Haiyan
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This article is from Scientific Reports , volume 4 . Abstract Surface plasmonics from metal nanoparticles have been demonstrated as an effective way of improving the performance of low-efficiency light emitters. However, reducing the inherent losses of the metal nanoparticles remains a challenge. Here we study the enhancement properties by Ag nanoparticles for InGaN/GaN quantum-well structures. By using a thin SiN dielectric layer between Ag and GaN we manage to modify and improve surface...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170193
PubMed Central
Sep 21, 2014 Rey-Barroso, Javier; Alvarez-Barrientos, Alberto; Rico-Leo, Eva; Contador-Troca, Maria; Carvajal-Gonzalez, Jose M; Echarri, Asier; del Pozo, Miguel A; Fernandez-Salguero, Pedro M
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This article is from Cell Communication and Signaling : CCS , volume 12 . Abstract Background: Adhesion and migration are relevant physiological functions that must be regulated by the cell under both normal and pathological conditions. The dioxin receptor (AhR) has emerged as a transcription factor regulating both processes in mesenchymal, epithelial and endothelial cells. Indirect results suggest that AhR could cooperate not only with additional transcription factors but also with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172968
PubMed Central
Sep 20, 2014 Haynes, Emma; Taylor, Kate P; Durey, Angela; Bessarab, Dawn; Thompson, Sandra C
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This article is from International Journal for Equity in Health , volume 13 . Abstract Introduction: The substantial gap in life expectancy between Indigenous and non-Indigenous Australians has been slow to improve, despite increased dedicated funding. Partnerships between Australian Indigenous and mainstream Western biomedical organisations are recognised as crucial to improved Indigenous health outcomes. However, these partnerships often experience challenges, particularly in the context of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169641
PubMed Central
Sep 20, 2014 Andrade, Gizely N; Molholm, Sophie; Butler, John S; Brandwein, Alice B; Walkley, Steven U; Foxe, John J
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This article is from Orphanet Journal of Rare Diseases , volume 9 . Abstract Background: Niemann-Pick type C (NPC) is an autosomal recessive disease in which cholesterol and glycosphingolipids accumulate in lysosomes due to aberrant cell-transport mechanisms. It is characterized by progressive and ultimately terminal neurological disease, but both pre-clinical studies and direct human trials are underway to test the safety and efficacy of cholesterol clearing compounds, with good success...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173006
PubMed Central
Sep 20, 2014 Bai, Chunxu; Yang, Yanling
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This article is from Nanoscale Research Letters , volume 9 . Abstract In the study, we investigate the Josephson supercurrent of a superconductor/normal metal/superconductor junction on the surface of a topological insulator, where a gate electrode is attached to the normal metal. It is shown that the Josephson supercurrent not only can be tuned largely by the temperature but also is related to the potential and the length of the weak-link region. Especially, the asymmetry excess critical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171575
PubMed Central
Sep 20, 2014 Hankins, Catherine A; Wainberg, Mark A; Weiss, Robin A
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This article is from Retrovirology , volume 11 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169638
PubMed Central
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This article is from International Journal for Equity in Health , volume 13 . Abstract Background: Health expectancy is a useful tool to monitor health inequalities. The evidence about the recent changes in social inequalities in healthy expectancy is relatively scarce and inconclusive, and most studies have focused on Anglo-Saxon and central or northern European countries. The objective of this study was to analyse the changes in socioeconomic inequalities in disability-free life expectancy in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169635
PubMed Central
Sep 20, 2014 Jiang, Jianxin; Zhang, Yi; Yu, Chao; Li, Zhipeng; Pan, Yaozheng; Sun, Chengyi
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This article is from Cancer Cell International , volume 14 . Abstract Background: Aberrant microRNA (miRNA) expression plays an essential role in the pathogenesis of Hepatocellular Carcinoma (HCC). However, specific involvement of miRNAs in HCC remains incompletely understood. The aim of this study was to explore the relevant microRNAs involved in the development of HCC. Methods: MicroRNA microarray was used to screen for the differentially expressed miRNAs in cancerous tissue and adjacent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172814
PubMed Central
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract Background: Measurement of mitral annulus (MA) dynamics is an important component of the evaluation of left ventricular (LV) diastolic function; MA velocities are commonly measured using tissue Doppler imaging (TDI). This study aimed to examine the clinical potential of a semi-automated cardiovascular magnetic resonance (CMR) technique for quantifying global LV diastolic function, using 3D volume tracking...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169226
PubMed Central
Sep 19, 2014 Lascar, Nadia; Kennedy, Amy; Hancock, Beverley; Jenkins, David; Andrews, Robert C.; Greenfield, Sheila; Narendran, Parth
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This article is from PLoS ONE , volume 9 . Abstract Background: Regular physical activity has recognised health benefits for people with T1DM. However a significant proportion of them do not undertake the recommended levels of activity. Whilst questionnaire-based studies have examined barriers to exercise in people with T1DM, a formal qualitative analysis of these barriers has not been undertaken. Our aims were to explore attitudes, barriers and facilitators to exercise in patients with T1DM....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169586
PubMed Central
Sep 19, 2014 Zhou, Peiran; Liu, Yi; Lv, Fang; Nie, Min; Jiang, Yan; Wang, Ou; Xia, Weibo; Xing, Xiaoping; Li, Mei
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This article is from PLoS ONE , volume 9 . Abstract Bruck syndrome (BS) is an extremely rare form of osteogenesis imperfecta characterized by congenital joint contracture, multiple fractures and short stature. We described the phenotypes of BS in two Chinese patients for the first time. The novel compound heterozygous mutations c.764_772dupACGTCCTCC (p.255_257dupHisValLeu) in exon 5 and c.1405G>T (p.Gly469X) in exon 9 of FKBP10 were identified in one proband. The novel compound heterozygous...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169569
PubMed Central
Sep 19, 2014 Mattsson, Johanna M.; Ravela, Suvi; Hekim, Can; Jonsson, Magnus; Malm, Johan; Narvanen, Ale; Stenman, Ulf-Hakan; Koistinen, Hannu
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This article is from PLoS ONE , volume 9 . Abstract Prostate-specific antigen (PSA or kallikrein-related peptidase-3, KLK3) exerts chymotrypsin-like proteolytic activity. The main biological function of PSA is the liquefaction of the clot formed after ejaculation by cleavage of semenogelins I and II in seminal fluid. PSA also cleaves several other substrates, which may explain its putative functions in prostate cancer and its antiangiogenic activity. We compared the proteolytic efficiency of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169579
PubMed Central
Sep 19, 2014 Hertlein, Gillian; Muller, Sebastian; Garcia-Gonzalez, Eva; Poppinga, Lena; Sussmuth, Roderich D.; Genersch, Elke
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This article is from PLoS ONE , volume 9 . Abstract The Gram-positive bacterium Paenibacillus larvae is the etiological agent of American Foulbrood. This bacterial infection of honey bee brood is a notifiable epizootic posing a serious threat to global honey bee health because not only individual larvae but also entire colonies succumb to the disease. In the recent past considerable progress has been made in elucidating molecular aspects of host pathogen interactions during pathogenesis of P....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169593
PubMed Central
Sep 19, 2014 Liu, Hongming; Lou, Guiyu; Li, Chongyi; Wang, Xiaodong; Cederbaum, Arthur I.; Gan, Lixia; Xie, Bin
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This article is from PLoS ONE , volume 9 . Abstract CYP2E1, one of the cytochrome P450 mixed-function oxidases located predominantly in liver, plays a key role in metabolism of xenobiotics including ethanol and procarcinogens. Recently, down-expression of CYP2E1 was found in hepatocellular carcinoma (HCC) with the majority to be chronic hepatitis B virus (HBV) carriers. In this study, we tested a hypothesis that HBx may inhibit CYP2E1 gene expression via hepatocyte nuclear factor 4α (HNF4α)....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169590
PubMed Central
Sep 19, 2014 Wang, Jia-Wei; Li, Jin-Ping; Song, Ying-Lun; Tan, Ke; Wang, Yu; Li, Tao; Guo, Peng; Li, Xiong; Wang, Yan; Zhao, Qi-Huang
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This article is from PLoS ONE , volume 9 . Abstract Background: A wealth of evidence based on the randomized controlled trials (RCTs) has indicated that surgery may be a better choice in the management of primary intracerebral hemorrhage (ICH) compared to conservative treatment. However, there is considerable controversy over selecting appropriate surgical procedures for ICH. Thus, this meta-analysis was performed to assess the effects of stereotactic aspiration compared to craniotomy in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169548
PubMed Central
Sep 19, 2014 Long, Linshuang; Ye, Hong
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This article is from Scientific Reports , volume 4 . Abstract A window is a unique element in a building because of its simultaneous properties of being “opaque” to inclement weather yet transparent to the observer. However, these unique features make the window an element that can reduce the energy efficiency of buildings. A thermochromic window is a type of smart window whose solar radiation properties vary with temperature. It is thought that the solar radiation gain of a room can be...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168269
PubMed Central
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This article is from Scientific Reports , volume 4 . Abstract Adiponectin (APN) is an adipocyte protein with anti-diabetic properties, which has been recently revealed to have anti-inflammatory activity in organ ischemia- reperfusion injury (IRI). However, little is known about its function in bile duct IRI after liver transplantation. Therefore, we investigated whether APN affects early warm IRI in rat bile duct using a liver autologous transplantation model. In our study, rats were randomly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168283
PubMed Central
Sep 19, 2014 Kangoye, David Tiga; Nebie, Issa; Yaro, Jean-Baptiste; Debe, Siaka; Traore, Safiatou; Ouedraogo, Oumarou; Sanou, Guillaume; Soulama, Issiaka; Diarra, Amidou; Tiono, Alfred; Marsh, Kevin; Sirima, Sodiomon Bienvenu; Bejon, Philip
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This article is from PLoS ONE , volume 9 . Abstract Background: Children below six months are reported to be less susceptible to clinical malaria. Maternally derived antibodies and foetal haemoglobin are important putative protective factors. We examined antibodies to Plasmodium falciparum merozoite surface protein 3 (MSP3) and glutamate-rich protein (GLURP), in children in their first two years of life in Burkina Faso and their risk of malaria. Methods: A cohort of 140 infants aged between...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169582
PubMed Central
Sep 19, 2014 Wang, Changji; Li, Yuan; Xia, Xiaonan; Zheng, Kangjia
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This article is from PLoS ONE , volume 9 . Abstract Revocation functionality is necessary and crucial to identity-based cryptosystems. Revocable identity-based encryption (RIBE) has attracted a lot of attention in recent years, many RIBE schemes have been proposed in the literature but shown to be either insecure or inefficient. In this paper, we propose a new scalable RIBE scheme with decryption key exposure resilience by combining Lewko and Waters’ identity-based encryption scheme and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169513
PubMed Central
Sep 19, 2014 Bockers, Estelle; Roepke, Stefan; Michael, Lars; Renneberg, Babette; Knaevelsrud, Christine
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This article is from PLoS ONE , volume 9 . Abstract Background: Previous research has identified a number of variables that constitute potential risk factors for victimization and revictimization. However, it remains unclear which factors are associated not only with childhood or adolescent victimization, but specifically with revictimization. The aim of this study was to determine whether risk recognition ability and other variables previously associated with revictimization are specifically...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169587
PubMed Central
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This article is from PLoS ONE , volume 9 . Abstract Background: Recent qualitative studies indicated that physicians interact with pharmaceutical representatives depending on the relative weight of the benefits to the risks and are also influenced by a variety of experiences and circumstances. However, these studies do not provide enough information about if, when, how and why their attitudes and behaviors change over time. Methods and Findings: A qualitative study using semi-structured...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169519
PubMed Central
Sep 19, 2014 Liu, Hongde; Zhu, Min; Mu, Yawen; Liu, Lingjie; Li, Guanghui; Wan, Yakun
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This article is from Bioscience Reports , volume 34 . Abstract Histone variant Htz1 substitution for H2A plays important roles in diverse DNA transactions. Histone chaperones Chz1 and Nap1 (nucleosome assembly protein 1) are important for the deposition Htz1 into nucleosomes. In literatures, it was suggested that Chz1 is a Htz1–H2B-specific chaperone, and it is relatively unstructured in solution but it becomes structured in complex with the Htz1–H2B histone dimer. Nap1 (nucleosome assembly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168335
PubMed Central
Sep 19, 2014 Cusso, Lorena; Vaquero, Juan Jose; Bacharach, Stephen; Desco, Manuel
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This article is from PLoS ONE , volume 9 . Abstract Purpose: Besides its application in oncology, 18F-FDG PET-CT imaging is also useful in the diagnosis of certain lung infections, inflammatory diseases, and atherosclerotic plaques. Myocardial uptake of 18F-FDG may hamper visualization of the lesions caused by these diseases. Two approaches have been proposed for reducing myocardial uptake in preclinical studies, namely, calcium channel blockers (verapamil) and high-fat diets such as commercial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169612
PubMed Central
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This article is from PLoS ONE , volume 9 . Abstract The genetic diversity of plants has traditionally been employed to improve crop plants to suit human needs, and in the future feed the increasing population and protect crops from environmental stresses and climate change. Genome-wide sequencing is a reality and can be used to make association to crop traits to be utilized by high-throughput marker based selection methods. This study describes a strategy of using next generation sequencing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169549
PubMed Central
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This article is from PLoS ONE , volume 9 . Abstract Spontaneous preterm birth is the leading cause of infant death and of neurological disabilities in survivors. A significant proportion of spontaneous preterm births are associated with infection. Infection activates inflammation which induces a cascade of events that leads to myometrial contractions and rupture of fetal membranes. In non-gestational tissues, the citrus flavone nobiletin has been shown to exert potent anti-inflammatory...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169627
PubMed Central
Sep 19, 2014 Summerton, Jean C.; Martin, Gregory M.; Evanseck, Jeffrey D.; Chapman, Michael S.
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This article is from PLoS ONE , volume 9 . Abstract Phosphoryl transfer reactions figure prominently in energy metabolism, signaling, transport and motility. Prior detailed studies of selected systems have highlighted mechanistic features that distinguish different phosphoryl transfer enzymes. Here, a top-down approach is developed for comparing statistically the active site configurations between populations of diverse structures in the Protein Data Bank, and it reveals patterns of hydrogen...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169622
PubMed Central
Sep 19, 2014 Jacquot, Adrien; Francius, Gregory; Razafitianamaharavo, Angelina; Dehghani, Fariba; Tamayol, Ali; Linder, Michel; Arab-Tehrany, Elmira
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This article is from PLoS ONE , volume 9 . Abstract Background: Liposomes are currently an important part of biological, pharmaceutical, medical and nutritional research, as they are considered to be among the most effective carriers for the introduction of various types of bioactive agents into target cells. Scope of Review: In this work, we study the lipid organization and mechanical properties of biomembranes made of marine and plant phospholipids. Membranes based on phospholipids extracted...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169657
PubMed Central
Sep 19, 2014 Szaloki, Gabor; Krasznai, Zoard T.; Toth, Agnes; Vizkeleti, Laura; Szollosi, Attila G.; Trencsenyi, Gyorgy; Lajtos, Imre; Juhasz, Istvan; Krasznai, Zoltan; Marian, Terez; Balazs, Margit; Szabo, Gabor; Goda, Katalin
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This article is from PLoS ONE , volume 9 . Abstract P-glycoprotein (Pgp) extrudes a large variety of chemotherapeutic drugs from the cells, causing multidrug resistance (MDR). The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10–40% of cell surface Pgps, while the rest becomes accessible to this antibody only in the presence of certain substrates or modulators (e.g. cyclosporine A (CsA))....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169599
PubMed Central
Sep 19, 2014 Guthikonda, Kranthi; Zhang, Hongmei; Nolan, Vikki G; Soto-Ramirez, Nelis; Ziyab, Ali H; Ewart, Susan; Arshad, Hasan S; Patil, Veeresh; Holloway, John W; Lockett, Gabrielle A; Karmaus, Wilfried
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This article is from Clinical Epigenetics , volume 6 . Abstract Background: The prevalence of asthma in girls increases after puberty. Previous studies have detected associations between sex hormones and asthma, as well as between sex hormones and T helper 2 (Th2) asthma-typical immune responses. Therefore, we hypothesized that exogenous or endogenous sex hormone exposure (represented by oral contraceptive pill (OCP) use and early menarche, respectively) are associated with DNA methylation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171400
PubMed Central
Sep 19, 2014 Albler, Christopher; Hollaus, Ralph; Kahlig, Hanspeter; Schmid, Walther
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This article is from Beilstein Journal of Organic Chemistry , volume 10 . Abstract Higher aminosugars are interesting targets in carbohydrate synthesis since these compounds play important roles in biological systems. However, their availability from natural sources is limited. Thus, in order to investigate their biological function, the development of facile and adaptable routes to this class of compounds is of fundamental importance. Our synthetic route towards these target molecules makes...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168925
PubMed Central
Sep 19, 2014 Hursel, Rick; Janssens, Pilou L. H. R.; Bouwman, Freek G.; Mariman, Edwin C.; Westerterp-Plantenga, Margriet S.
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This article is from PLoS ONE , volume 9 . Abstract Introduction: Green tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the functional COMT Val108/158Met polymorphism that are associated with COMT enzyme activity; high-activity enzyme, COMTH(Val/Val genotype),...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169515
This article is from BMJ Open , volume 4 . Abstract Objective: The chronic care model is an increasingly used approach to improve the quality of care through system changes in care delivery. While theoretically these system changes are expected to increase productive patient–professional interaction empirical evidence is lacking. This study aims to identify the influence of quality of care on productive patient–professional interaction. Setting: Longitudinal study in 18 Dutch regions....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170203
This article is from BMJ Open , volume 4 . Abstract Objectives: To synthesise contributing factors leading to medicine-related problems (MRPs) in adult patients with cardiovascular diseases and/or diabetes mellitus from their perspectives. Design: A systematic literature review of qualitative studies regarding the contributory factors leading to MRPs, medication errors and non-adherence, followed by a thematic synthesis of the studies. Data sources: We screened Pubmed, EMBASE, ISI Web of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170202
PubMed Central
Sep 19, 2014 Kagerer, Sabine; Wehrum, Sina; Klucken, Tim; Walter, Bertram; Vaitl, Dieter; Stark, Rudolf
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This article is from PLoS ONE , volume 9 . Abstract We investigated the impact of sexual stimuli and the influence of sexual motivation on the performance in a dot-probe task and a line-orientation task in a large sample of males and females. All pictures (neutral, erotic) were rated on the dimensions of valence, arousal, disgust, and sexual arousal. Additionally, questionnaires measuring sexual interest/desire/motivation were employed. The ratings of the sexual stimuli point to a successful...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169562
PubMed Central
Sep 19, 2014 Kambe, Takashi; Oshima, Kokichi
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This article is from Scientific Reports , volume 4 . Abstract We report here the direct evidence of the existence of a permanent electric dipole moment in both crystal phases of a fullerene-based magnet—the ferromagnetic α-phase and the antiferromagnetic α′-phase of tetra-kis-(dimethylamino)-ethylene-C60 (TDAE-C60)—as determined by dielectric measurements. We propose that the permanent electric dipole originates from the pairing of a TDAE molecule with surrounding C60 molecules. The two...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168275
PubMed Central
Sep 19, 2014 Thorsen, Kristian; Agafonov, Oleg; Selst?, Christina H.; Jolma, Ingunn W.; Ni, Xiao Y.; Drengstig, Tormod; Ruoff, Peter
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This article is from PLoS ONE , volume 9 . Abstract Homeostatic and adaptive control mechanisms are essential for keeping organisms structurally and functionally stable. Integral feedback is a control theoretic concept which has long been known to keep a controlled variable robustly (i.e. perturbation-independent) at a given set-point by feeding the integrated error back into the process that generates . The classical concept of homeostasis as robust regulation within narrow limits is often...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169565
PubMed Central
Sep 19, 2014 Rizzo, Manglio; Bayo, Juan; Piccioni, Flavia; Malvicini, Mariana; Fiore, Esteban; Peixoto, Estanislao; Garcia, Mariana G.; Aquino, Jorge B.; Gonzalez Campana, Ariel; Podesta, Gustavo; Terres, Marcelo; Andriani, Oscar; Alaniz, Laura; Mazzolini, Guillermo
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This article is from PLoS ONE , volume 9 . Abstract We have shown that ex vivo pre-conditioning of bone marrow-derived dendritic cells (DC) with low molecular weight hyaluronan (LMW HA) induces antitumor immunity against colorectal carcinoma (CRC) in mice. In the present study we investigated the effects of LMW HA priming on human-tumor-pulsed monocytes-derived dendritic cells (DC/TL) obtained from healthy donors and patients with CRC. LMW HA treatment resulted in an improved maturation state...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169605
PubMed Central
Sep 19, 2014 Horbach, Tina; Chi, Tabughang Franklin; Gotz, Claudia; Sharma, Satyan; Juffer, Andre H.; Dimova, Elitsa Y.; Kietzmann, Thomas
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This article is from PLoS ONE , volume 9 . Abstract The upstream stimulatory factor 2 (USF2) is a regulator of important cellular processes and is supposed to have also a role during tumor development. However, the knowledge about the mechanisms that control the function of USF2 is limited. The data of the current study show that USF2 function is regulated by phosphorylation and identified GSK3β as an USF2-phosphorylating kinase. The phosphorylation sites within USF2 could be mapped to serine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169611
PubMed Central
Sep 19, 2014 Verhagen, Johan; Gabrysova, Leona; Shepard, Ella R.; Wraith, David C.
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This article is from PLoS ONE , volume 9 . Abstract In vitro induced Foxp3+ T regulatory (iTreg) cells form a novel and promising target for therapeutic tolerance induction. However, the potential of these cells as a target for the treatment of various immune diseases, as well as the factors involved in their development and function, remain debated. Here, we demonstrate in a myelin basic protein (MBP)-specific murine model of CNS autoimmune disease that adoptive transfer of antigen-specific...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169598
PubMed Central
Sep 19, 2014 Fiala, Ondrej; Zahorakova, Daniela; Pospisilova, Lenka; Kucerova, Jana; Matejckova, Milada; Martasek, Pavel; Roth, Jan; Ruzicka, Evzen
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This article is from PLoS ONE , volume 9 . Abstract Objective: The aim of the study is to determine the frequency of parkin allelic variants in Czech early-onset Parkinson's disease patients and healthy controls. Methods: A total of 70 early-onset Parkinson's disease patients (age at onset ≤40 years) and 75 controls were screened for the sequence variants and exon rearrangements in the parkin gene. Results: Parkin mutations were identified in five patients (7.1%): the p.R334C point mutation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169530